The sox2 transcription factor binds rna

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August undefined, 2024

WebApr 14, 2024 · SOX2 can bind directly to ES2 lncRNA with high affinity through its DNA-binding HMG domain [144]. Numerous studies have reported aberrant expression of SOX2 … WebMar 13, 2024 · We report the unprecedented finding that the conserved RNA-binding motif protein, RBM24, positively controls Sox2 mRNA stability and is necessary for optimal SOX2 mRNA and protein levels in development, perturbation of which causes ocular defects, including microphthalmia and anophthalmia.

Alternate Roles of Sox Transcription Factors beyond Transcription ...

WebDownloadable! Certain transcription factors are proposed to form functional interactions with RNA to facilitate proper regulation of gene expression. Sox2, a transcription factor … WebApr 14, 2024 · Since SOX2 was reported to directly bind to the upstream regulatory region of human papillomavirus E6 to ... To identify genes regulated by SOX2, RNA sequencing (RNA-Seq) was performed in SOX2-OE and Ctl U251 cells. ... Ma YX, Ying MY et al. Reprogramming Transcription Factors Oct4 and Sox2 Induce a BRD-Dependent Immunosuppressive … bring and braai catering

Transcription factor is not just a transcription factor - ScienceDirect

WebJan 10, 2024 · Transcription factors (TFs) interact with several other proteins in the process of transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions … WebNov 23, 2015 · NANOG is a transcription factor that occupies single-copy loci, as well as TEs including the ERV1 repeat family and LTR7 sequences in pluripotent stem cells 14, 24. We observed that HPAT2,... WebNov 26, 2024 · SRY-box transcription factor 2 (SOX2) overlapping transcript (SOX2-OT) is an evolutionarily conserved long noncoding RNA. Its intronic region contains the SOX2 gene, the major regulator of the pluripotency of embryonic stem cells. The human SOX2-OT gene comprises multiple exons and has multiple tran … bring backward meaning

High throughput screening identifies SOX2 as a super pioneer factor …

Sox2ot binds YY1 in an RNA immunoprecipitation (RIP

WebJan 1, 2003 · The transcription factor SOX2 has also been implicated in the regulation of Fgf4 expression. We have used gene targeting to inactivate Sox2, examining the phenotypic consequences in mutant embryos and in chimeras in which the epiblast is rescued with wild-type ES cells. We find a cell-autonomous requirement for the gene in both epiblast and ... WebFatima Cavaleri, Hans Schöler, in Handbook of Stem Cells, 2004. OCT4 DOES NOT PLAY SOLO. Regulation of the FGF4 and UTF genes has provided insight into an Oct4-induced … brine ratio for picklesWebApr 10, 2024 · p21-activated kinase 2 binds to transcription factor SOX2 and up-regulates DEK to promote the progression of lung squamous cell carcinoma. Long non-coding RNA … bring back the old kraft dinner

"WebSep 23, 2024 · However, SOX2 is a transcription factor, which makes direct targeting difficult. Thus, MLN4924 appears to be a promising SOX2-targeting agent via SOX2 depletion at the transcription level by inactivation of the FBXW2–MSX2 axis to abrogate cancer stem cells and to overcome drug resistance, 2 major causes of cancer therapeutic … " - The sox2 transcription factor binds rna

The sox2 transcription factor binds rna

SOX2 downregulation of PML increases HCMV gene expression …

WebApr 14, 2024 · Sox2 binds this RNA with an affinity equivalent to that of ssDNA and non-consensus DNA (Fig. 1a, b ). These data reveal that Sox2 can directly interact with RNA in … WebApr 30, 2024 · Lately, Sox2 was identified as an RNA-binding protein that contains no classic RNA-binding motifs. Sox2 is able to directly interact with RNA. It recognizes G/C-rich RNA …

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WebJul 24, 2013 · The transcription factor SRY (sex-determining region)-box 2 (SOX2) is an important functional marker of neural precursor cells (NPCs) and plays a critical role in self-renewal and neuronal differentiation; however, the molecular mechanisms underlying its functions are poorly understood. WebSeveral recent studies have revealed that the Sox2 transcription factor binds RNA through its high-mobility group box (HMGB) domain in vitro and in vivo. A high degree of …

WebJul 1, 2005 · Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been described to drive pluripotent-specific expression of a number of genes. We now extend the list of Sox2-Oct4 target genes to include Nanog. Within the … WebConclusion. Although the transcription factor Sox2 is generally thought of as a regulator of stem cell maintenance and regulation of differentiation, its role in orchestrating the many …

WebAug 15, 2024 · The Sox2 transcription factor binds RNA. Nat. Commun. 2024; 11: 1805. Crossref; PubMed; Scopus (45) Google Scholar]. These TFs with DNA- and RNA-binding function can therefore orchestrate diverse cellular metabolisms by fine-tuning the expression of target genes at both transcriptional and post-transcriptional levels. … WebMar 2, 2024 · INTRODUCTION. Essential cellular processes such as replication, recombination, and DNA repair occur alongside transcription on DNA. During transcription, RNA polymerase II (RNAPII) pauses at discrete sites, which in some instances is required for proper regulation of gene expression (1, 2).Prolonged pausing and/or stalling of the …

WebApr 14, 2024 · Sox2 binds this RNA with an affinity equivalent to that of ssDNA and non-consensus DNA (Fig. 1a, b ). These data reveal that Sox2 can directly interact with RNA in vitro and that its...

WebJun 25, 2012 · The mitochondrial transcription factor A (mtTFA) is central to assembly and initiation of the mitochondrial transcription complex. Human mtTFA (h-mtTFA) is a dual high mobility group box (HMGB) protein that binds site-specifically to the mitochondrial genome and demarcates the promoters for recruitment of h-mtTFB1, h-mtTFB2 and the ... bring me items with a twistWebMay 31, 2024 · Transcription factors are proteins that bind to specific DNA sequences and control the rate at which genes are transcribed to produce messenger RNA [46]. bring me my red bag with my makeupWebCofactor flavin adenine dinucleotide (FAD), a compound with flavin moiety and a derivative of riboflavin (vitamin B2), is shown to bind to Sox9 (a key transcription factor in early pancreatic development) and, subsequently, induce a large increase in markers of pancreatic development, including Ngn3 and PTF1a. Pyridoxal 5′-phosphate (PLP), the active form of … bring a guest invitation