WebJun 24, 2016 · The ERK1/2 MAPK pathway is subject to a large number of negative feedback loops. These include direct phosphorylation by ERK1/2 (and RSK2) as well as transcriptionally induced feedback regulators, such as DUSPs and Sprouty proteins. The major negative feedback loops acting on the ERK1/2 pathway are shown. WebOct 12, 2016 · RSK2 in vitro phosphorylation, immunoblot analysis and activity assay For activation of RSK2, 4.8 μM samples of RSK2 were incubated in 0.05 μM of PDK1 and 0.047 μM of ERK (final concentration) in 20 mM Tris buffer containing 500 mM NaCl, 10 mM of MgCl2, and 200 μM of ATP at room temperature for 2 hrs.

Phosphorylation of H2AX at Ser139 and a New Phosphorylation …

WebKnow comprehensive RSK2 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction. U.S.A. English. Chinese( … WebJul 6, 2024 · Overexpression of RSK2 leads to vemurafenib resistance, and the deletion of RSK2 inhibits cell proliferation and sensitizes melanoma cells to vemurafenib. Mechanistically, RSK2 enhances the phosphorylation of FOXO1 by interacting with FOXO1 and promoting its subsequent degradation, leading to upregulation of cyclin D1 in … ferrari lyrics james hype

Functional Phosphoproteomics in Cancer …

WebHere, we found that 90 kDa ribosomal protein S6 kinase 2 (RSK2) could form a physical complex with Pin1, leading to phosphorylation of Pin1 at Ser (16) ex vivo and in vitro respectively. WebPrimary Target: RSK2 505300 View Pricing & Availability Bulk Size or Custom Request Recommended Products Overview Supporting Documentation Related Product & Applications Overview Description References Product Information Biological Information Physicochemical Information Storage and Shipping Information Packaging Information WebRSK2 phosphorylation of p53 may help regulate chromatin structure and cell cycle (6). RSK2 is prominently expressed in the brain and is essential for cognitive function and learning. … ferrari itália