WebSep 3, 2012 · The human Pin1 WW domain is a small autonomously folding protein that has been useful as a model system for biophysical studies of β-sheet folding. This domain … WebPIN1 is expressed in the protoderm, its polarity facing the cotyledon initiation sites, and in the vasculature, where polarity is facing downwards ( Benkova et al., 2003 ). The …
WW Protein Domain Proline-rich Motifs Cell Signaling Technology
WebFeb 13, 2013 · For example, NMR experiments have shown that the WW domain of Pin1 binds to both pT(212)-P-S and to pT(231)-P-P of Tau, but the PPIase domain only binds to the pT(212)-P-S site, indicating that the +1 proline may confer WW domain-specificity (Smet et al., 2004, 2005). The WW domain-specific nature of the pT(231)-P-P site may also make … WebDec 12, 2024 · Here we study the enzyme Pin1, which features two flexibly thethered domains, the binding domain (WW) and the catalytic domain (PPI), that undergo coupled structural rearrangements. We present multi-state structures of the WW domain of the free form and in complex with two antagonizing ligands determined by experimentally-derived … how to check a cat for diabetes
Critical role of WW domain phosphorylation in regulating
WebJan 25, 2002 · Moreover, both Pin1 and WW domain mutants refractory to Ser(16) phosphorylation act as dominant-negative mutants to induce mitotic block and … WebThe Pin1 Domain. Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) – a 34-residue protein – is depicted above in two different ways. On the left, the reverse turns are easily seen in green, while the β-strands are seen in yellow. ... These proline residues can be seen as red side chains in the image of the Pin1 WW domain below ... WebPIN1. The human parvulin PIN1 (EC 5.2.1.8, 163aa) is a nuclear protein implicated in the regulation of mitosis through interaction with CDC25 and polo-like kinase-1. From: The … michelin sport cup 2 speed rating