WebA senolytic (from the words senescence and -lytic, "destroying") is among a class of small molecules under basic research to determine if they can selectively induce death of … Web谷粉学术论坛提供了文献求助板块,助力于帮助需要求助外文文献及疑难文献的网友,
Photoactivatable Reagents, Including Photoreactive …
WebReference: Photoactivatable senolysis with single-cell resolution delays aging. Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo. Citing article. Our main focus in designing this senolytic prodrug was ensuring the accurate delivery of the photosensitive drug to SnCs for precise and controllable yet complete senolysis with single-cell resolution. We then report a prodrug strategy to design a photosensitive senolytic agent activated by SA-β-gal, an enzyme … See more The fluorescence spectra and the absorption spectra of KSL0608-O and KSL0608-Se were evaluated. Escherichia coli β-gal (E. coli β-gal), as the SA-β-gal model … See more We then examined the ability of KSL0608-O and KSL0608-Se to convert oxygen into reactive oxygen species (ROS) after photoirradiation using a commercial ROS … See more Before cell imaging, the cytotoxicity of our compounds was evaluated, and both compounds exhibited low cytotoxicity (Supplementary Fig. 2). Human ovarian cancer … See more Senescent MRC-5 cells at passage 40 (P40) were co-incubated with KSL0608-O or KSL0608-Se and commercial staining dyes targeting different organelles. The NIR … See more litter of newborn kittens
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WebPhotoactivatable senolysis with single-cell resolution delays aging. / Shi, Donglei; Liu, Wenwen; Gao, Ying et al. In: Nature Aging, 02.02.2024. Research output: Contribution to … WebPhotoactivatable fluorescent dyes, which are generally colorless and nonfluorescent until photolyzed with UV light, are particularly useful for investigating cell lineage and for … WebNotably, the elimination of senescent cells (senolysis) was recently reported to improve normal and pathological changes associated with aging in mice (Baker et al., 2016;Xu et al., 2024) and the ... litter of puppies in spanish