High affinity copper uptake protein

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August undefined, 2024

WebBecause copper uptake at the cell membrane is a crucial step in copper acquisition, yeast genes encoding the high affinity copper transport proteins are tightly regulated in response to copper levels to ensure that … WebHuman CTR1 is a high-affinity copper transporter that also mediates the uptake of the anticancer drug cisplatin by largely unknown transport mechanisms. Here we report the 6 …

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Web30 de dez. de 2005 · High affinity copper binding by wild type PrP has been confirmed by the independent techniques indicating the presence of specific tight copper binding sites … WebIt was shown that a gene, CTR1, encoded a multispanning plasma membrane protein that was specifically required for high affinity copper transport into yeast.The CTR1 gene product is a protein composed of 406 amino acid residues. A second high affinity copper uptake protein, encoded by the CTR3 gene, was subsequently identified. The two gene … chino hills entertainment

Molecular Characterization of hCTR1, the Human Copper Uptake Protein*

WebProtein target information for High affinity copper uptake protein 1 (house mouse). Find diseases associated with this biological target and compounds tested against it in … WebGene ID: 102804936, updated on 5-Feb-2024. Summary Other designations. high affinity copper uptake protein 1-like Web5 de abr. de 2024 · Ctr1, a high-affinity copper transporter, is a homotrimeric integral membrane protein that provides the main route for cellular copper uptake. Together with … chino hills equine hospital

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6M97: Crystal structure of the high-affinity copper transporter Ctr1

Web1 de out. de 2002 · High affinity copper uptake protein 1 Gene Slc31a1 Status UniProtKB reviewed (Swiss-Prot) Organism Mus musculus (Mouse) Amino acids 196 Protein … WebThe redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. However, little is known … chino hills facility reservationWebOne way that some methanotrophs obtain copper is by production and secretion of methanobactins (Mbns), ribosomally synthesized, posttranslationally modified peptide natural products that bind Cu I with high affinity ().The protein machinery to manufacture and transport Mbns is encoded by operons, which are down-regulated under copper … chino hills event venues

"High affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais " - High affinity copper uptake protein

High affinity copper uptake protein

Web149 Likes, 9 Comments - Joshua Rubin (@realfoodgangstas) on Instagram: "10 Things You Can Do Today to Replenish Zinc Status to Support Thyroid Health Lets talk about ... Web8 de abr. de 2024 · HIGHLIGHTS. who: Nina Salustros from the (UNIVERSITY) have published the research: Structural basis of ion uptake in copper-transporting P1B-type ATPases, in the Journal: (JOURNAL) of 16/08/2024 what: Transport and regulation mechanism Based on detailed analyses of the structurally determined E1 state and …

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WebHigh CTR1 Expression is associated with poor response to chemotherapy in Muscle-invasive Bladder Cancer. Gene silencing of either CTR1 or DMT1 did not affect copper … Web16 de mar. de 2010 · Copper and iron are essential elements employed in pathways that are conserved in all kingdoms of life. In eukaryotes, several interdependent connections between copper and iron homeostasis have been described previously ().For example, high-affinity iron uptake in Saccharomyces cerevisiae is mediated by multicopper …

Web5 de jun. de 2001 · Previously, we described a human gene (CTR1;SLC31A1) that encodes a high-affinity copper-uptake protein and hypothesized that this protein is required for … Webalthough the role of Ctr1 internalization in copper uptake is currently unclear. Furthermore, exposure of yeast cells to high copper concentrations ($10 mM) triggers the degradation of Ctr1 at the plasma membrane in a mechanism that is inde-pendent of endocytosis and vacuolar proteases (14). The Ctr1 and Ctr3 high affinity copper transport ...

Web11 de abr. de 2024 · To investigate whether Met44 residue in COPT1 is also sufficient for copper acquisition, we converted Met44 to alanine in the full-length COPT1 protein, and transformed this mutant allele [COPT1(M44A)] into S. cerevisiae ctr1Δctr3Δ strain which lacks high affinity copper transporters CTR1 and CTR3 and cannot grow on … WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at protein level Annotation score 5/5 Entry Feature viewer Publications External links History BLAST Download Add a publication Entry feedback Function

Web12 de abr. de 2024 · To overcome this challenge, bacteria synthesize high-affinity iron-binding molecules called siderophores, which are recognized by specific transporters on the cell surface. Trojan horse antibiotics have evolved to hijack these transporters for uptake across the outer membrane (OM).

Web1 de abr. de 2024 · The CTR1 gene of Saccharomyces cerevisiae encodes a protein required for high affinity copper uptake. The protein is expressed on the plasma membrane, is heavily glycosylated with O-linkages, and ... granite school district contactWebCTR1, high affinity copper uptake protein 1; ATP7A, copper-transporting ATPase 1; CCO, cytochrome C oxidase; ATOX1, copper transport protein ATOX1; KRAS, Kirsten rat sarcoma 2 viral oncogene homolog. Display full size. Figure 1. KRAS-driven colorectal cancer (CRC) cells are addicted to copper metabolism. granite school district closuresWebProtein High affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence … chino hills equine veterinary hospitalWeb5 de jan. de 2024 · high affinity copper uptake protein 1, copper transporter 1, solute carrier family 13 (sodium/sulphate symporters), member 1 GeneRIFs: Gene … granite school district days offWebCatalog FieldsAntigen: High affinity copper uptake protein 1Available to For-Profits: YesAntigen Species: HumanHybridoma Cells Available (Non-Profit): NoIsotype: MIgG2bDepositor: Clinical Proteomics Technologies for CancerHost Species: mouseAntigen Sequence: Positive Tested Species Reactivity: HumanDepositors Institution: National … chino hills family optometry chino hills caWebHigh affinity copper uptake protein 1 Alternative names Copper transporter 1 ( rCTR1) Liver regeneration-related protein LRRGT00200 Solute carrier family 31 member 1 … granite school district employment utahWebWe ascertain the ability of these proteins to functionally complement and transport copper in the corresponding Saccharomyces cerevisiae high-affinity copper transport mutant. The specific expression pattern of the Arabidopsis COPT1–5 mRNA in different tissues was analyzed by RT-PCR. chino hills fire breaking news