WebSep 29, 2024 · The transcription factor p53 is a tumor suppressor gene that plays an important role in regulating cell growth, apoptosis, and DNA repair. Mutations in the p53 gene occur in half of all human malignant tumors ( 7 – 9 ). In recent years, evidence indicates that p53 plays a protective role in inflammatory response by inhibiting the ... WebAug 2, 2024 · Of note, the CTCF phospho-depletion mutant S224E resulted in dysregulation of hundreds of target genes, including p53 and p21 . CTCF was found to be a substrate for LATS kinase, and cellular-stress-induced activity of LATS directly phosphorylates CTCF’s zinc finger (ZF) linker and selectively dissociates CTCF from a small fraction of its ...
A multi-omics integrative analysis based on CRISPR screens re …
Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs in its structure. CTCF's binding is disrupted by See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease". Trends Genet. 17 (9): 520–7. See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more WebFeb 7, 2024 · The oncogene CTCFL (BORIS), the paralog of CTCF, is a transcriptional factor highly expressed in ovarian cancer (but in rarely any other tissue in females) with cancer-specific characteristics and ... shure wireless instrument microphone
CTCF and Its Partners: Shaper of 3D Genome during Development
WebNov 10, 2024 · p53 is a transcription factor that suppresses tumor growth through regulation of dozens of target genes with diverse biological functions. ... Insulation by CTCF chromatin boundaries in specific ... http://genesdev.cshlp.org/content/28/7/723.full WebNov 25, 2024 · Using Hi-C data, we observe spatial coupling between differentially expressed genes and their differentially accessible regulatory elements and reveal two … shure wireless microphone accessories