WebNov 1, 2008 · Purpose: The purpose of this study was to develop and validate HPLC-UV method for the determination of the cisplatin, based …
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WebCisplatin is an anti-tumor agent widely employed in cancer chemotherapy. A specific and selective method for the quantitative determination of cisplatin in human plasma and its … WebFeb 16, 2024 · severe or ongoing nausea and vomiting; vision problems, pain behind your eyes; hearing problems, ringing in your ears; pain, redness, swelling, or skin changes …
WebHPLC is a useful technique for monitoring 2 and 3, but only if the components of the mobile phase used in the reverse phase HPLC technique are unreactive toward these aqua complexes under the conditions of the experiment. 15N Nuclear magnetic resonance (NMR) with samples highly enriched (>98%) in 15N has been used to check the reactivity of 2 … WebJul 13, 2015 · Cisplatin is one of the first-choice drugs for the treatment of many cancers but it is not without its disadvantages, principally toxicity to the liver, kidney, brain and gastrointestinal tract, the initiation of hearing loss, and suppression of bone marrow.
WebApr 1, 2012 · The HPLC method was developed using C 18 ODS Hypersil column of 250 × 4.6 mm id with 5 µm particle size, mobile phase of water : methanol : acetonitrile (40:35:25, v/v/v, pH 3.5) at a flow rate... WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often …
WebAug 15, 2007 · Paclitaxel and platinum analogs (cisplatin and carboplatin) is one such FDA approved combination administered sequentially for the treatment of different types of cancers; for example carboplatin in combination with paclitaxel is an approved therapy in patients with non small cell lung cancer (NSCLC), advanced and recurrent cervical …
WebNov 1, 2008 · We found that AGT is readily cross-linked to DNA in the presence of cisplatin. HPLC-ESI⁺-MS/MS sequencing of tryptic peptides originating from dG-Pt-AGT complexes revealed that the cross-linking ... philosophers stone first edition worthWebJan 7, 2024 · Cancer is known to be one of the major causes of death nowadays. Among others, chemotherapy with cisplatin is a commonly used treatment. Although widely employed, cisplatin is known to cause severe side effects, such as nerve and kidney damage, nausea, vomiting, and bone marrow suppression. Most importantly, a number … tshedimosho mehlaleng psWebC is-diamminedichloroplatinum(II) (cisplatin) is the most celebrated metal-based chemotherapeutic in the history of modern medicine.The discovery of its anticancer effects was not only opportune [1,2,3], especially during a period when cancer prevention was desperately needed, but also because medical oncology did not yet exist as a clinical … philosophers stone by van morrisonWebMar 11, 2024 · Cisplatin (CDDP), a platinum-based drug, is the most potent anti-cancer agent and is widely used for cancer treatment [ 1 ]. In particular, it plays crucial roles in … tshedimosetsoWebCisplatin Synonyms: cis-Diammineplatinum (II) dichloride, cis-Dichlorodiammine platinum (II), cis-Platinum (II) diammine dichloride, Cisplatin Linear Formula: Pt (NH3)2Cl2 CAS Number: 15663-27-1 Molecular Weight: 300.05 EC Number: 239-733-8 Product Comparison Guide Use the product attributes below to configure the comparison table. philosophers-stone.info purebloodWebApr 14, 2024 · To isolate [*Pt]cisplatin, preparative HPLC was performed using a polymer-based aqueous size exclusion chromatography (SEC) column (OHpak SB-2004, Shodex, Showa Denko, Tokyo, Japan) at a flow... tshedimosetso meaningWebFeb 28, 2024 · Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels. Xiaoxu Zhao 1 Department of General Surgery, ... HPLC analysis detected high concentrations of cisplatin in tumors after combined therapy, both of which indicated that the delivery efficacy of cisplatin was … tshedimosho mehlaleng primary school